|Publication Type:||Journal Article|
|Year of Publication:||2012|
|Authors:||Abbaskhan, A, Choudhary, MIqbal, Ghayur, MNabeel, Parween, Z, Shaheen, F, Gilani, A-ul-H, Maruyama, T, Iqbal, K, Tsuda, Y|
|Keywords:||antioxidant activity, cytotoxicity, Indian celery, Seseli, Seseli diffusum, spasmogenic activity, spasmolytic activity|
In continuation of our work on Indian celery (Seseli diffusum (Roxb. ex Sm.) Santapau & Wagh; Umbelliferae), the fractionation of the 80% MeOH–H2O extract of the seeds was performed to identify the principles responsible for its folk use as an antispasmodic and diuretic. Several compounds were isolated as active components: seselin (1) and anthriscinol methyl ether (4) showed a selective cytotoxicity to some yeast strains. Compound 1 also showed spasmolytic activity. On the other hand, isopimpinellin (3) and isorutarin (5) exhibited a spasmogenic effect on the smooth muscle preparations. Compound 5 was also found to have antioxidant activity. Among them, compound 4 was isolated for the first time from this plant. Copyright © 2011 John Wiley & Sons, Ltd.
|Short Title:||Phytotherapy Research|