Conserved Noncoding Sequences Highlight Shared Components of Regulatory Networks in Dicotyledonous Plants

Publication Type:Journal Article
Year of Publication:2012
Authors:Baxter, L, Jironkin, A, Hickman, R, Moore, J, Barrington, C, Krusche, P, Dyer, NP, Buchanan-Wollaston, V, Tiskin, A, Beynon, J, Denby, K, Ott, S
Journal:The Plant Cell
Volume:24
Issue:10
Date Published:2012
ISBN Number:10404651
Keywords:Populus, Vitis, Vitis vinifera
Abstract:

Conserved noncoding sequences (CNSs) in DNA are reliable pointers to regulatory elements controlling gene expression. Using a comparative genomics approach with four dicotyledonous plant species (Arabidopsis thaliana, papaya [Carica papaya], poplar [Populus trichocarpa], and grape [Vitis vinifera]), we detected hundreds of CNSs upstream of Arabidopsis genes. Distinct positioning, length, and enrichment for transcription factor binding sites suggest these CNSs play a functional role in transcriptional regulation. The enrichment of transcription factors within the set of genes associated with CNS is consistent with the hypothesis that together they form part of a conserved transcriptional network whose function is to regulate other transcription factors and control development. We identified a set of promoters where regulatory mechanisms are likely to be shared between the model organism Arabidopsis and other dicots, providing areas of focus for further research.

URL:http://www.jstor.org/stable/23327033
Short Title:The Plant Cell
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