Publication Type: | Journal Article |
Year of Publication: | 2011 |
Authors: | Ahmed, F, Toume, K, Ohtsuki, T, Rahman, M, Sadhu, SKumar, Ishibashi, M |
Journal: | Phytotherapy Research |
Volume: | 25 |
Issue: | 1 |
Date Published: | 2011 |
ISBN Number: | 1099-1573 |
Keywords: | AGS cell lines, cryptolepine, Malvaceae, Sida, Sida acuta, TRAIL-induced apoptosis |
Abstract: | Bioassay guided separation of Sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2–3). Compound 1 showed strong activity in overcoming TRAIL-resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 μm. Combined treatment of 1 and TRAIL sensitized AGS cells to TRAIL-induced apoptosis at the aforementioned concentrations. Copyright © 2010 John Wiley & Sons, Ltd. |
URL: | http://dx.doi.org/10.1002/ptr.3219 |
Short Title: | Phytotherapy Research |
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