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Cryptolepine, isolated from Sida acuta, sensitizes human gastric adenocarcinoma cells to TRAIL-induced apoptosis

Publication Type:Journal Article
Year of Publication:2011
Authors:Ahmed, F, Toume, K, Ohtsuki, T, Rahman, M, Sadhu, SKumar, Ishibashi, M
Journal:Phytotherapy Research
Volume:25
Issue:1
Date Published:2011
ISBN Number:1099-1573
Keywords:AGS cell lines, cryptolepine, Malvaceae, Sida, Sida acuta, TRAIL-induced apoptosis
Abstract:

Bioassay guided separation of Sida acuta whole plants led to the isolation of an alkaloid, cryptolepine (1), along with two kaempferol glycosides (2–3). Compound 1 showed strong activity in overcoming TRAIL-resistance in human gastric adenocarcinoma (AGS) cells at 1.25, 2.5 and 5 μm. Combined treatment of 1 and TRAIL sensitized AGS cells to TRAIL-induced apoptosis at the aforementioned concentrations. Copyright © 2010 John Wiley & Sons, Ltd.

URL:http://dx.doi.org/10.1002/ptr.3219
Short Title:Phytotherapy Research
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