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Dissecting Arabidopsis Gβ Signal Transduction on the Protein Surface

Publication Type:Journal Article
Year of Publication:2012
Authors:Jiang, K, Frick-Cheng, A, Trusov, Y, Delgado-Cerezo, M, Rosenthal, DM, Lorek, J, Panstruga, R, BOOKER, FITZGERALDL, Botella, JRamón, Molina, A, ORT, DONALDR, Jones, AM
Journal:Plant Physiology
Volume:159
Issue:3
Date Published:2012
ISBN Number:00320889
Abstract:

The heterotrimeric G-protein complex provides signal amplification and target specificity. The Arabidopsis (Arabidopsis thaliana) Gβ-subunit of this complex (AGB1) interacts with and modulates the activity of target cytoplasmic proteins. This specificity resides in the structure of the interface between AGB1 and its targets. Important surface residues of AGB1, which were deduced from a comparative evolutionary approach, were mutated to dissect AGB1-dependent physiological functions. Analysis of the capacity of these mutants to complement well-established phenotypes of Gβ-null mutants revealed AGB1 residues critical for specific AGB1-mediated biological processes, including growth architecture, pathogen resistance, stomata-mediated leaf-air gas exchange, and possibly photosynthesis. These findings provide promising new avenues to direct the finely tuned engineering of crop yield and traits.

URL:http://www.jstor.org/stable/41549916
Short Title:Plant Physiology
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