IBIS-Flora

Angiosperm Flora of India

Rhodiola-induced inhibition of adipogenesis involves antioxidant enzyme response associated with pentose phosphate pathway

Publication Type:Journal Article
Year of Publication:2011
Authors:Lee, O-H, Kwon, Y-I, Apostolidis, E, Shetty, K, Kim, Y-C
Journal:Phytotherapy Research
Volume:25
Issue:1
Date Published:2011
ISBN Number:1099-1573
Keywords:antioxidant enzyme response, pentose phosphate pathway, phenolics, proline dehydrogenase, reactive oxygen species, Rhodiola crenulata, tyrosol
Abstract:

The aim of this study was to investigate whether Rhodiola crenulata extract and tyrosol, a major bioactive phenolic compound present in Rhodiola, change the activities of endogenous antioxidant enzyme response (AER) and energy pathways linked to proline-mediated pentose phosphate pathway (PPP) during adipogenesis. Treatment with Rhodiola extracts inhibited the activities of proline dehydrogenase (PDH) and glucose-6-phosphate dehydrogenase (G6PDH) as well as lipid accumulation and reactive oxygen species (ROS) production. The inhibition of PDH and G6PDH activities by Rhodiola likely prevented proline oxidation required for critical ATP generation that is coupled to AER via the PPP, leading to inhibition of adipogenesis. Rhodiola extracts dose-dependently increased superoxide dismutase (SOD) activity, resulting in a reduced ROS level during adipogenesis. Moreover, the effects of tyrosol, a major bioactive compound in Rhodiola species, were directly correlated with all observed effects by Rhodiola extracts. These results indicate that the antiadipogenic effects of Rhodiola extracts can be attributed to a phenolic tyrosol that may potentially disrupt proline-mediated energy generation and AER via PPP, resulting in the suppression of adipogenesis and lipid accumulation. This further provides a biochemical rationale to identify the roles of phenolics that modulate the cellular redox environment and therefore have relevance for obesity management. Copyright © 2010 John Wiley & Sons, Ltd.

URL:http://dx.doi.org/10.1002/ptr.3236
Short Title:Phytotherapy Research
Fri, 2014-01-24 22:17 -- admin
https://secure.gravatar.com/avatar/5ade1b012674ce3dd941e2ea5dd15cc1.jpg?d=https%3A//flora.indianbiodiversity.org/sites/all/modules/patches/contrib/gravatar/avatar.png&s=100&r=G
Scratchpads developed and conceived by (alphabetical): Ed Baker, Katherine Bouton Alice Heaton Dimitris Koureas, Laurence Livermore, Dave Roberts, Simon Rycroft, Ben Scott, Vince Smith