Systems Analysis of Plant Functional, Transcriptional, Physical Interaction, and Metabolic Networks

Publication Type:Journal Article
Year of Publication:2012
Authors:Bassel, GW, Gaudinier, A, Brady, SM, Hennig, L, Rhee, SY, De Smet, I
Journal:The Plant Cell
Volume:24
Issue:10
Date Published:2012
ISBN Number:10404651
Abstract:

Physiological responses, developmental programs, and cellular functions rely on complex networks of interactions at different levels and scales. Systems biology brings together high-throughput biochemical, genetic, and molecular approaches to generate omics data that can be analyzed and used in mathematical and computational models toward uncovering these networks on a global scale. Various approaches, including transcriptomics, proteomics, interactomics, and metabolomics, have been employed to obtain these data on the cellular, tissue, organ, and whole-plant level. We summarize progress on gene regulatory, cofunction, protein interaction, and metabolic networks. We also illustrate the main approaches that have been used to obtain these networks, with specific examples from Arabidopsis thaliana, and describe the pros and cons of each approach.

URL:http://www.jstor.org/stable/23327028
Short Title:The Plant Cell
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Scratchpads developed and conceived by (alphabetical): Ed Baker, Katherine Bouton Alice Heaton Dimitris Koureas, Laurence Livermore, Dave Roberts, Simon Rycroft, Ben Scott, Vince Smith