Publication Type: | Journal Article |
Year of Publication: | 2010 |
Authors: | Palu, A, Su, C, Zhou, B-N, West, B, Jensen, J |
Journal: | Phytotherapy Research |
Volume: | 24 |
Issue: | 10 |
Date Published: | 2010 |
ISBN Number: | 1099-1573 |
Keywords: | A2A, mechanisms, Morinda, Morinda citrifolia, PDGF, Rubiaceae, wound closure rate |
Abstract: | Morinda citrifolia L. (Rubiaceae) commonly known as noni, has been used in Polynesia by traditional healers for the treatment of cuts, bruises and wounds. Our objective was to investigate the wound-healing mechanisms of the noni leaf. The investigations of its wound-healing mechanisms were carried out using fresh noni leaf juice (NLJ), noni leaf ethanol extract (NLEE) and its methanol (MFEE) and hexane (HFEE) fractions on the PDGF and A2A receptors in vitro and topically in mice. Fresh noni leaf juice showed significant affinity to PDGF receptors, and displayed 166% binding inhibition of the ligand binding to its receptors, while at the same concentration, it only had 7% inhibition of the ligand binding to the A2A receptors. NLEE, HFEE and MFEE showed significant affinity to A2A receptors, concentration dependently, with IC50 values of 34.1, 42.9 and 86.7 μg/mL, respectively. However, MFEE significantly increased wound closure and reduced the half closure time in mice with a CT50 of 5.4 ± 0.2 days compared with control (p < 0.05). These results suggest that noni leaf significantly accelerated wound healing in mice via its ligand binding to the PDGF and A2A receptors as its probable mechanisms of wound-healing and also support its traditional usage for wound-healing in Polynesia. Copyright © 2010 John Wiley & Sons, Ltd. |
URL: | http://dx.doi.org/10.1002/ptr.3150 |
Short Title: | Phytotherapy Research |
Wound healing effects of noni (Morinda citrifolia L.) leaves: a mechanism involving its PDGF/A2A receptor ligand binding and promotion of wound closure
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